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Are there any contraindication for patients with gilbert's syndrome to take antimalarials?

Associated tags: anti-malarials, contraindications, Gilbert's syndrome, Infectious disease, malaria

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Question answered:04/12/07 Warning! this question is over two years old.

We found no specific information stating that antimalarials are contraindicated (or indeed safe) in patients with Gilbert’s syndrome.

We looked at the SPCs for Mefloquine [1], Proguanil [2] and Chloroquine [3] and neither mentioned Gilbert’s syndrome. To see the specific sections on contraindications follow these links:

Mefloquine http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=1701#CONTRAINDICATIONS

Proguanil http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=756#CONTRAINDICATIONS

Chloroquine http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=2272#CONTRAINDICATIONS

For more specific advice you may want us to refer the question to a specialist medicines information unit. If you would like us to do this let us know via ‘Contact us’ (http://www.clinicalanswers.nhs.uk/index.cfm?action=contact)

References

1) http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=1701
2) http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=756
3) http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=2272

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