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Is there any evidence that leukotriene antagonists have any role to play in the treatment of perennial or vasomotor rhinitis (not allergic rhinitis)? Has there been any recent peer review of the treatment of these two problems?

Associated tags: ENT, leukotriene antagonists, rhinitis

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Question answered:16/11/06 Warning! this question is over two years old.

We could find no clinical trials of leukotriene antagonists in non-allergic rhinitis to answer your question. However we did find one 2005 study ‘Efficacy of montelukast in the treatment of nasal polyposis’ (1) which may be of interest.

“OBJECTIVES: Twenty-four consecutive patients with symptomatic nasal polyposis and nonallergic or perennial rhinitis who were undergoing chronic nasal steroid therapy were prospectively evaluated for response to adjunctive oral montelukast sodium therapy. CONCLUSIONS: These results suggest that montelukast appears to be beneficial for some patients with nasal polyposis. Patients with perennial allergies and nasal polyposis seem more likely to respond to the treatment than those with nonallergic nasal polyposis.”

References

1. Kieff DA, Busaba NY. Efficacy of montelukast in the treatment of nasal polyposis. : Ann Otol Rhinol Laryngol. 2005 Dec;114(12):941-5

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