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Question answered:19/05/08
This is a difficult area for the NLH Q&A Service. Much of the research literature is presented by condition and therefore symptom-led questions are more problematic for us.
GP Notebook has a section dealing with raised ESR [1] which might be of interest and this includes a section on investigations for raised ESR of unknown aetiology [2]
The website wrong diagnosis lists three potential causes of raised ESR and CRP [3] and these are:
“1. Arthritis
2. Connective tissue disorders
3. Vasculitis”
With regard to raised globulins a previous answer of ours [4] highlights potential causes, dependent on the type of globulin (e.g. alpha or beta globulin).
References
1) http://www.gpnotebook.co.uk/simplepage.cfm?ID=362414125
2) http://www.gpnotebook.co.uk/simplepage.cfm?ID=-1113980901&linkID=14583&cook=yes
3) http://symptoms.wrongdiagnosis.com/cosymptoms/raised-esr/raised-crp.htm
4) http://nelh2004.sequence.co.uk/index.cfm?question=2313
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