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Is there evidence that oral fluconazole is effective in treating Tinea Unguium?

Associated tags: Dermatology, fluconazole, fungal nail, Infectious disease, oral administration, tinea unguium

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	confidence		moderate

Question answered:05/06/08

A 2003 guideline on onychomycosis from the British Association of Dermatologists [1] reports:

“Systemic therapy

The three drugs currently licensed for general use in onychomycosis are listed in Table 2. The two other systemic agents available for oral use, ketoconazole and fluconazole, are not licensed for nail infection. Ketoconazole may be used in some recalcitrant cases of yeast infection affecting the nails but cannot be prescribed for dermatophyte onychomycosis because of problems with hepatotoxicity. The use of fluconazole thus far has concentrated on vaginal candidiasis and systemic yeast infections although it is active against dermatophytes. There are some published studies of its use in nail infection but the dose and duration of treatment are not yet clear and it is not licensed for this indication in the U.K., nor does it appear likely to be so in the near future.”

We could find no new trials of fluconazole published since the above guideline.

References

1) http://www.bad.org.uk/healthcare/guidelines/Onychomycosis.pdf

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