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A total of 6322 clinical questions available

Is there any evidence for effectiveness of Questran in the treatment of IBS?

Associated tags: cholestyramine, Gastroenterology, IBS

Question DetailsView Comments (0)

ANSWER

provided by Attract

Moderate

Appraisal

Moderate

Confidence

Poor

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Answer Rating key

	search		strong
	appraisal		weak
	confidence		moderate

Question answered:23/05/08

Following a search of Cochrane, TRIP database and Pubmed, we have found no trials for the effectiveness of questran in the treatment of IBS. We did find a paper (1) on the management of IBS which reports:

“In some patients with severe diarrhea, bile acids may lead to decreased reuptake of water from the colon. As such, the bile acid sequestrant, cholestyramine (Questran), may be a useful second-line agent for diarrhea-predominant IBS. “

However, this level of evidence is graded as consensus opinion.

1. http://www.aafp.org/afp/20021115/1867.html

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