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Question answered:18/02/08
A 1996 article [1] studied the effect of extended parietal cell vagotomy (EPCV) on long-term nutritional status and digestive-absorption function. They reported:
“Vitamin B12, folacin, intrinsic factor and iron protein level of serum in the EPCV group were slightly decreased as compared with those of the control group (P > 0.05)”
A 1991 paper [2] reported:
“Intrinsic factor is produced by the gastric parietal cell. Its secretion is stimulated via all pathways known to stimulate gastric acid secretion: histamine, gastrin, and acetylcholine. There is, however, a different mode of secretion for both substances: atropine, vagotomy, and H2 receptor antagonists inhibit both intrinsic factor and acid secretion...”
A 1984 paper [3] examined the serum concentration of vitamin B12, blood hemoglobin, and gastric acid secretion capacity, preoperatively and 1 and 5 years after proximal gastric vagotomy (PGV) in 15 patients. This reported:
“There was a significant reduction in the mean concentration of vitamin B12 at 1 year, but this disappeared within 5 years after PGV. The serum concentration of vitamin B12, however, remained at all times within the health-related reference interval. The blood hemoglobin concentration was unaltered during the follow-up period. The decrease in gastric acid secretion capacity gained by PGV was permanent, and no tendency to increased acidity was observed during the 5-year period. The temporary decrease in serum concentration of vitamin B12 reflects a PGV-induced diminished production of intrinsic factor in the parietal cells. In the characterization of parietal cell function the determination of serum vitamin B12 concentration is, however, much less sensitive than gastric acid secretion tests. The observed change in vitamin B12 concentration after PGV was subclinical, self-corrected, and thus required no treatment.”
References
1) http://www.ncbi.nlm.nih.gov/pubmed/9275372
2) http://www.ncbi.nlm.nih.gov/pubmed/1775933
3) http://www.ncbi.nlm.nih.gov/pubmed/6740222
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